Structure-activity Relationships for Interactions between Carbapenems
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چکیده
activity and a wide spectrum against both Gram-positive and Gram-negative bacteria1~4). This high activity is due to good diffusion through the outer membranein Gram-negative organisms5), high affinities for penicillinbinding proteins (PBPs)6'7) and high stability and inhibitory activity against /Mactamases8). However, carbapenems were hydrolyzed by dehydropeptidase-I (DHP-I) from several animals. In previous paper, we
منابع مشابه
Structure-activity Relationships of Carbapenems to the Antagonism of the Antipseudomonal Activity of Other /J-Lactam Agents and to the /J-Lactamase Inducibility in Pseudomonas aeruginosa: Effects of ljS-Methyl Group and C-2 Side Chain
The antagonism of the antipseudomonal activity of ceftazidime by meropenem(la) was much less than those by imipenem (2a) and panipenem (2b). To reveal the major structural features of carbapenem compounds responsible for the antagonism, we investigated the structure-activity relationships of carbapenems to their antagonism of the antipseudomonal activity of ceftazidime and to their /Mactamase-i...
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